ÿþ<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN" "http://www.w3.org/TR/html4/loose.dtd"> <html> <head> <meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1"> <title>EASL 2011 - Poster Presentations</title> <link rel="stylesheet" type="text/css" href="style.css"> </head> <body> <table width="750" align="center" border="0" cellspacing="0" cellpadding="0" class="MainTable"> <tr> <td><img src="http://www2.kenes.com/liver-congress/PublishingImages/top_ei.jpg" width="760" height="129" /></td> </tr> <tr> <td class="content"><p><b>Abstracts on line are sponsored by</b><br /> <img src="../logo_janssen.jpg" /></p><h1>Poster Presentations</h1> <P><b>Session Title:</b> Category 06: Non-invasive markers of liver fibrosis<br><b>Presentation Date:</b> 31 MAR, 2011</P><h2 align='left'><B><B><B>COMPARISON OF FIBROSIS DEGREE CLASSIFICATION ACCURACY BY LIVER BIOPSY AND NON-INVASIVE TESTS IN CHRONIC HEPATITIS C</B></B></B></h2> <p align='left'><b>J. Boursier</b><sup>1</sup>*, S. Bertrais<sup>2</sup>, F. Oberti<sup>1</sup>, Y. Gallois<sup>1</sup>, I. Fouchard-Hubert<sup>1</sup>, N. Dib<sup>1</sup>, M.-C. Rousselet<sup>1</sup>, J.-P. Zarski<sup>3</sup>, P. Calès<sup>1</sup>, Multicentric Groups of SNIFF 17, VINDIAG 7, Metavar 4, and ANRS HC EP 23 Fibrostar Studies<br> <em><sup>1</sup>University Hospital, <sup>2</sup>University, Angers, <sup>3</sup>University Hospital, Grenoble, France. *jeboursier@chu-angers.fr</em></p><br> <p align='justify'><b><b>Background: </b> </b>Non-invasive tests have been constructed and evaluated mainly for binary diagnoses such as significant fibrosis. Recently, detailed fibrosis classifications for several non-invasive tests have been developed, but their accuracy has not been evaluated in comparison to liver biopsy, especially in clinical practice. <b><br><b>Aims: </b></b> The main aim of the present study was to evaluate the accuracy of detailed fibrosis classifications available for non-invasive tests and liver biopsy. The secondary aim was to evaluate these accuracies in independent populations. <b><br><b>Methods: </b> </b>Four HCV populations provided 2068 patients with liver biopsy, four different pathologist skill-levels and non-invasive tests. Results were expressed as percentages of correctly classified patients. <b><br><b>Results: </b> </b>In population #1 including 205 patients and comparing liver biopsy (reference: consensus reading by two experts) and blood tests, Metavir fibrosis (F<sub>M</sub>) stage accuracy was 64.4% in local pathologists vs. 82.2% (p< 10<sup>-3</sup>) in single expert pathologist. Significant discrepancy (e"2 F<sub>M </sub>vs reference histological result) rates were: Fibrotest: 17.2%, FibroMeter<sup>2G</sup>: 5.6%, local pathologists: 4.9%, FibroMeter<sup>3G</sup>: 0.5%, expert pathologist: 0% (p< 10<sup>-3</sup>). In population #2 including 1056 patients and comparing only blood tests, accuracies of detailed fibrosis classification vs. the usual accuracies of binary diagnosis for significant fibrosis (F<sub>M</sub>e"2) were, respectively: Fibrotest: 37.9% vs. 74.5%, p< 10<sup>-3</sup>; FibroMeter<sup>2G</sup>: 74.9% vs. 78.1%, p=0.025, FibroMeter<sup>3G</sup>: 86.9% vs. 77.9%, p< 10<sup>-3</sup>. In population #3 (and #4) including 458 (359) patients and comparing blood tests and Fibroscan, accuracies of detailed fibrosis classification were: Fibrotest: 42.5% (33.5%), Fibroscan: 64.9% (50.7%), FibroMeter<sup>2G</sup>: 68.7% (68.2%), FibroMeter<sup>3G</sup>: 77.1% (83.4%), p< 10<sup>-3</sup> (p< 10<sup>-3</sup>). Significant discrepancy (e"2 F<sub>M</sub>) rates were, respectively: Fibrotest: 21.3% (22.2%), Fibroscan: 12.9% (12.3%), FibroMeter<sup>2G</sup>: 5.7% (6.0%), FibroMeter<sup>3G</sup>: 0.9% (0.9%), p< 10<sup>-3</sup> (p< 10<sup>-3</sup>). <b><br><b>Conclusions: </b></b> The accuracy in detailed fibrosis classification of the best-performing blood test outperform liver biopsy read by a local pathologist, i.e., in clinical practice. This detailed classification accuracy is much lower than that of significant fibrosis with Fibroscan and even Fibrotest, but higher with FibroMeter<sup>3G</sup>. FibroMeter classification accuracy was significantly higher than those of other non-invasive tests. Thus, for hepatitis C cared in clinical practice, fibrosis degree can be evaluated using an accurate blood test.</p> <br><a href='Session-P1.06.htm'>Back</a><br> <p>&nbsp;</p> <p>&nbsp;</p></td> </tr> </table> </body> </html>